Speaker: Professor Maxime Descoteaux (Université de Sherbrooke – Canada)
Date: February 27, 2024
Time: 4 PM – 5 PM
Venue: C1 (ERB) – Room 120

The Center for Brain and Health (CBH) is pleased to invite you to an upcoming live seminar with the guest speaker Professor Maxime Descoteaux, from Université de Sherbrooke – Canada, which will take place on Tuesday, February 27, 2024 at 4 PM (GST) in C1 (ERB) – room 120, on the topic of challenges and opportunities in white matter tractography to quantify neuroinflammation, demyelination and axonal disruption.

Abstract

This talk will focus on the 160,000 km of human brain white matter, its integrity and how non-invasive diffusion MRI can be used to develop novelbiomarkers sensitive to demyelination, axonal disruption and neuroinflammation. I will cover what tractography and tractometry can do well and what are some of the important current tractography limitations such as the length, position, shape and gyral biases, and will present some solutions that start addressing these limitations using machine learning, anatomical priors and advanced acquisition methods. The lack of ground truth on long‐range connectivity of the human brain makes it hard to quantitatively evaluate results. A key challenge for future tractography algorithms will be to control for false positives, while identifying the full extent of existing fiber bundles.